Comparative placebo-controlled clinical study of efficacy of reverse transcriptase inhibitor for health improvement and prevention of age-related diseases in aging sled dogs
We initiated a clinical trial where inhibition of retrobiome activity will be tested as an anti-aging and cancer-prevention approach in 8-11 year old “retired” sled dogs. We have recruited 102 dogs from kennels across North America and accommodated them at Cornell University Veterinary School.
When participating dogs arrive at Vaika’s kennel, they are subjected to a complete health check. This includes tests defining their immune system performance , check for possible tumors and sites of arthritis; determination of locomotor activity and exercising potential and genetic analysis for baseline activity of retrobiome.
What happens at Cornell University?
The following parameters are evaluated at the baseline and at several time-points during treatment:
Cancer, heart disease, arthritis
Treadmill, pull test
T-cell activity, cytokine levels
Object recognition, playfulness
Changes in cytokines levels upon physical activity
Cognitive dysfunction tests
State of innate immunity
State of adaptive immunity
What happens at Roswell Park Comprehensive Cancer Center?
DNA test = Status of Retrobiome
Correlation with diseases, frailty and longevity
What will this study bring?
Happy senior life
Our animals will spend their elderly years under attention of THE best specialists in dogs health.
We believe that proposed treatment will significantly postpone the time of the onset of aging related diseases, therefore making dogs healthy life longer
We believe that under the treatment dogs will live not only happier and healthier, but longer
Friends will stay
Our ultimate goal is to learn how to extend life of mammals, so that our friends can stay with us longer
Unique knowledge on biology of aging
We will learn study mechanisms of immune system exhaustion and genetic ground of age-related diseases
Clues for life-extension
We will learn if suggested approach is capable of life extension